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Department of Neuropathology was started by Dr. S.
Sriramachari in 1959
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:Dept of Neuropathology :
. About Dept /Home
. Objectives
. Human resource development
. Infrastructure
. Clinical services
. Brain bank
. Research
. Contributions
. Growth and Development
. Future Plans
. Faculty Profile
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along with Neurosurgery and Neurology. In 1974 Dr. D. H. Deshhpande, joined as Professor
and later in 1982 Prof. Sarala Das took over as Professor and Head of the Department.
OBJECTIVES:
The main objectives of the department are Diagnostic Service,
Research and Human resource development.
HUMAN RESOURCE DEVELOPMENT:
The faculty has been imparting short-term training in
Neuropathology to students of DM Neurology, M.Ch Neurosurgery and M.D Psychiatry since 1975.
Weekly brain cutting sessions and slide seminars are conducted to promote active interaction
with Clinicians, Neuroradiologists, Microbiologists and Pathologists. Training in
Neuropathology, for a period of one of three months is provided to Junior faculty and students of
Pathology.
INFRASTRUCTURE:
Well established Histopathology laboratory with processing
facility with automatic tissue processing facility with Automatic Tissue Processor and Microtomy
(Rotary Microtomes and Sledge Microtomes). Facility to large paraffin sections of the Brain,
Transmission Electron Microscope and Ultra Microtomy with accessories.
Transfusion Medicine Centre managed by the Department of Pathology has
facility for large volume plasmapharesis component separation.At Clinical pathology laboratory
all Haematological parameters are estimated by automated cell counter.
CLINICAL SERVICES
The services includes Histopathology laboratory, Autopsy
services, Electron Microscopy Laboratory and Brain Bank services.
BRAIN BANK
Brain Bank (with special reference to pathological states)
started with the financial support of DST, DBT and ICMR as National Facility to promote research
in Neurobiology using human neuron tissues. The brain tissue collected with informed
consent of those relatives within 4-24 hours following death are frozen for Biochemial,
Immuno-histochemical and Molecular Biological studies. Large number of formalin fixed brain
tissue from various Neurological, Neurosurgical and Psychiatric disorders are available for
study.
A related News Link:
India's only Brain Bank needs more Grey Matter
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RESEARCH:
Department believes in interdepartmental and
inter-institutional collaboration to pursue the research.
The areas of research interest are -
- Infections of Nervous system
- Neuro AIDS and Viral Encephalitis
- Pathology of Developmental disorders
- Neuro Oncology
CONTRIBUTIONS:
- Detailed Neuropathological studies on Japanese Encepalitis, HSV,
Rabies, HIV Viral Encephalitis.
- Pathology of Neurotuberculosis, with special reference to
involvement of Hypothalamus and Brain and its relation to sudden death.
- Study of Cytoskeletal Pathology in normal ageing and Alzheimer's
disease, Parkinson's disease and ALS.
- Descriptive Epidemiology of CJD in India.
- Established routine diagnostic laboratory for Myopathology
(including Histochemistry, Immunohistochemistry and Ultrastructural study).
- Pathology of Lafora body disease, Ceroid Lipofuscinosis,
Myoclonic Epilepsy, Mitochondrial Myopathy and Dystropohinopathies.
- Detailed study to assess regeneration across pretreated
peripheral nerve Allograft by cold preservation without Immunosuppression - studied on rat
sciatic nerve grafts.
- Expression of p67 (MUNC- 18), a noval neuronal protein and
regulator of CDK - 5 has been studied in developing rat and human fatal nervous system and in
adult rat and human brains and in human CNS tumors.
- Biology of Neuroepithelial tumors with emphasis on recurrent
Neoplasma.
GROWTH AND DEVELOPMENT:
Initially department started Histopathology, in 1976 the Brain
Bank and Clinical Pathology Laboratory including emergency laboratory at Neurocentre were added.
Round-the-clock service was made available from emergency laboratory service and blood bank with
active collaboration from Department of Microbiology and Neurochemistry.
FUTURE PLANS:
Stress is more on quality man power development in the field
of Neuropathology including short term training courses in Diagnostic Myopathology for
Pathologists, Electronic Microscopy and Blood Banking to Medical Laboratory technicians.
In case of research, Molecular Biology for in-depth
evaluation of Neuro-degenerative disease and Neuro-infection, to support the diagnosis is
envisaged. Biology of Brain tumors, the interaction between cell proliferation and apoptosis in
the progression of the tumors, especially in paediatric age group will be the future line of
study. Attempts are in progress to evolve objective pathomorphological criteria for diagnosis of
muscle disorders by systematic evaluation of the retrospective and prospective material. The
Human Brain Bank will continue to function and brain tissue from infective conditions will also
be stored fresh, for research purposes.
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